One of the Iranian regime's most powerful figures has been killed in a U.S. airstrike near Baghdad's international airport, the Pentagon has confirmed. Why it matters: Qasem Soleimani, the leader of the elite Quds force of the Iranian Revolutionary Guard Corps (IRGC), was as revered by Iran's proxies and supporters across the region as he was reviled by Iran's foes, who considered him the mastermind of state-sponsored terrorism. "At the direction of the President, the U.S. military has taken decisive action to protect U.S. personnel abroad by killing Qasem Soleimani." — Pentagon statement The big picture: Soleimani was often referred to as Iran's second most powerful person, behind Ayatollah Ali Khamenei. Tehran can be expected to respond forcefully to his assassination, and the already tense U.S.-Iran standoff will instantly become far more dangerous — including for U.S. forces in the region. What they're saying: "General Soleimani was actively developing plans to attack American diplomats and service members in Iraq and throughout the region. General Soleimani and his Quds Force were responsible for the deaths of hundreds of American and coalition service members and the wounding of thousands more. ... General Soleimani also approved the attacks on the U.S. Embassy in Baghdad that took place this week." — Pentagon statement "Soleimani was an enemy of the United States. That’s not a question. The question is this — as reports suggest, did America just assassinate, without any congressional authorization, the second most powerful person in Iran, knowingly setting off a potential massive regional war?" — Sen. Chris Murphy (D-Conn.) "The defensive actions the U.S. has taken against Iran & its proxies are consistent with clear warnings they have received. They chose to ignore these warnings because they believed [Trump] was constrained from acting by our domestic political divisions. They badly miscalculated." — Sen. Marco Rubio (R-Fla) "The consequences of killing Soleimani are hard to grasp; this is the biggest news in the Middle East for years. For starters, the US will have to leave Syria soon & the Iraq presence is likely on its way out too." — Charles Lister, Middle East Institute Behnam Ben Taleblu of the Foundation for the Defense of Democracies tells Axios this is "one of the most significant security events in modern Middle Eastern history." "While Soleimani has institutionalized at least some of his war-fighting aptitudes within the [IRGC], what isn’t institutionalized is his name-brand and charisma," he adds. Mahdi al-Muhandis, founder of the Iran-backed Iraqi militia Kataib Hezbollah, was also reported dead. Kataib Hezbollah responded to deadly airstrikes by the U.S. on Sunday with two days of violent protests outside the U.S. embassy in Baghdad. Defense Secretary Mark Esper said Thursday that there were indications that Iran or its proxies may be planning additional attacks, and that the U.S. was prepared to take preemptive action. “The game has changed,” he said. “And we’re prepared to do what is necessary to defend our personnel and our interests and our partners in the region.” President Trump threatened to retaliate after the chaotic scenes at the embassy, but has also said he doesn’t want war. He previously cancelled airstrikes on Iran at the last minute after the downing of a U.S. drone in June, concerned by the prospect of escalation. There are few steps that could have guaranteed swifter retaliation than the assassination of Soleimani. Oil prices were up roughly 3% within hours of the attack. Jason Bordoff, head of a Columbia University energy think tank, predicted via Twitter that Iran's response "certainly may include escalating attacks on energy infrastructure." He said the major September aerial strikes against Saudi Arabia's oil infrastructure, which the U.S. blamed on Iran, were "just the beginning."